Severity Predictor for Infectious Diseases
Diagnostic method capable of predicting severity of symptoms of infectious diseases days prior to their manifestation.
Spread of COVID-19 uncovered a significant drawback in diagnostics of infectious diseases. Human immune response can cause more harm than the related infection itself, and therefore treatments based on symptoms may come too late.
Severity Predictor utilizes a PCR-based detection of a specific biomarker in nasopharyngeal swabs. Higher levels of the biomarker are detectable days prior to manifestation of symptoms of an already ongoing infectious disease and the values are dependent on severity of the upcoming symptoms.
Diagnostics of Kidney Diseases
Reliable and simple diagnosis of hereditary kidney disease ADTKD (Autosomal Dominant Tubulo-Interstitial Kidney Disease).
Presented solution utilizes a specifically developed ELISA-based method for detection of mutated form of MUC1 protein—which causes kidney failure in ADTKD patients—in blood plasma. The ELISA technique is time-proven, doesn’t require any complicated instrumentation, and can be performed even in makeshift conditions. Therefore, it can be used as a first, inexpensive step in complex nephrology diagnostics.
Unlike genetic testing, the ELISA-based method can monitor plasmatic levels of MUC1 protein in real-time. Therefore, it allows monitoring of disease progression as well as efficiency of an applied therapy.
Prediction of Pregnancy Complications
Solution for prediction of onset of various complications during pregnancy though analysis of blood samples collected during a first-trimester screening, i.e., between 10th and 13th week of pregnancy.
Our method for prediction of pregnancy complications has a potential to cause a revolution in prenatal care. By monitoring a specific set of biomarkers in a blood sample, it can predict set of pregnancy complications with a significantly high success rate as early as during 10th week of pregnancy.
We have technologies that enable the realization of a new lab-on-chip universal platform without the use of external devices.
Solution providing a diagnostic method based on passive chips equipped with nanofluidic structures for complex sample work-up, analyte detection, and result visualization.
Such methods can be performed anywhere—even in field conditions—with simple execution and without complicated instrumentation. Analysis can be robust with fast results and simple readout for a low price.
Solutions for collection of biological samples via nasopharyngeal swabs and from saliva for various applications.
viRNAtrap Collection Tube is an innovative solution for storing and transport of nasopharyngeal swabs. Certification for CE IVD is underway.
Salivette Collection Tube system (CE IVD) is an easy-to-use method for collection of saliva samples proven to be tolerated also by children.
Nucleic Acid Extraction
Solution for fast, efficient, and effortless isolation of nucleic acids from biological samples.
viRNAtrap Extraction Kit presents a high-throughput system for both automatic and manual isolation of RNA and DNA based on magnetic beads.
Isolation of viral RNA from nasopharyngeal swabs – IVDR (in cooperation with IMMUNOTECH s.r.o, Prague, Czech Republic)
Isolation of RNA/DNA from blood/plasma/serum/urine (in cooperation with IMMUNOTECH s.r.o, Prague, Czech Republic)
Human NGS Diagnostic
We have a versatile methodology for creating NGS kits that can be custom developed in collaboration with business partners.
Currently under development is a kit for diagnostics of multiple myeloma – a malignant bone marrow disorder caused by the uncontrolled proliferation of myeloma cells in the bone marrow. Presented solution is based on an in-house developed, innovative approach for determination of the cause of this disease using a custom set of oligonucleotides in a well-defined panel for NGS sequencing followed by a bioinformatics analysis allowing to directly determine the cause of this disease.
We have a versatile methodology for creating NGS kits that can be custom developed in collaboration with business partners for detection of human pathogens.
Our innovative approach has been used to design a custom set of oligonucleotides for an effortless, amplicon-based sequencing of SARS-CoV-2 genome. The whole genome sequence is determined by sequencing a set of PCR amplicons covering the whole genome region or by sequencing fragments of the virus genome obtained by their specific enrichment using synthetically prepared complementary oligonucleotides.
Dry Blood Spot
Solution for simple and reliable diagnostics of various genetic disorders using dry-blood-spot sampling
Dry blood spot is a convenient way for sampling, storage, and transport of blood samples. Few drops of blood, drawn by lancet from a finger, heel, or toe, are absorbed into a porous paper and air dried. Such samples are easy to handle and safe to store and transport. Subsequently, DNA or proteins can be isolated from the sample for further analysis.
Isolation of nucleic acids from dry spot blood
Protein Isolation from dry spot blood